2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. TRP Channel

TRP Channel

Transient receptor potential channels

TRP Channel

Related Products

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TRP Channel (Transient receptor potential channel) is a group of ion channels located mostly on the plasma membrane of numerous human and animal cell types. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC ("C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA. In group 2, there are TRPP ("P" for polycystic) and TRPML ("ML" for mucolipin). Many of these channels mediate a variety of sensations like the sensations of pain, hotness, warmth or coldness, different kinds of tastes, pressure, and vision. TRP channels are relatively non-selectively permeable to cations, including sodium, calcium and magnesium. TRP channels are initially discovered in trp-mutant strain of the fruit fly Drosophila. Later, TRP channels are found in vertebrates where they are ubiquitously expressed in many cell types and tissues. TRP channels are important for human health as mutations in at least four TRP channels underlie disease.

TRP Channel Isoform Specific Products:

TRP Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-108462R
    ML-SA1 (Standard)
    		Agonist
    ML-SA1 (Standard) is the analytical standard of ML-SA1 (HY-108462). This product is intended for research and analytical applications. ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral.
    ML-SA1 (Standard)
  • HY-110189R
    Pregnenolone monosulfate sodium (Standard)
    		Activator
    Pregnenolone monosulfate (sodium) (Standard) is the analytical standard of Pregnenolone monosulfate (sodium). This product is intended for research and analytical applications. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication. Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.
    Pregnenolone monosulfate sodium (Standard)
  • HY-134268
    8-Br-7-CH-ADPR
    		Antagonist
    8-Br-7-CH-ADPR (8-Bromo-7-deazaadenosine-5'-O-diphosphoribose) is a specific TRPM2 antagonist that inhibits TRPM2 activation by binding to the NUDT9 homology domain of the TRPM2 channel, thereby controlling the influx of cations through the cell membrane channel. 8-Br-7-CH-ADPR can be used to study the role of TRPM2 in pathological processes such as cell death, neurodegenerative diseases, myocardial infarction, and diabetes.
    8-Br-7-CH-ADPR
  • HY-108329R
    AM-0902 (Standard)
    		Antagonist
    AM-0902 (Standard) is the analytical standard of AM-0902 (HY-108329). This product is intended for research and analytical applications. AM-0902 is a potent, selective transient receptor potential A1 (TRPA1) antagonist with IC50s of 71 and 131 nM for rTRPA1 and hTRPA1, respectively.
    AM-0902 (Standard)
  • HY-169780
    (S)-AMG-628
    		Antagonist
    (S)-AMG-628 (Compound 16q) is the S-isomer of AMG-628 (HY-123374). (S)-AMG-628 is the orally active antagonist for TRPV1, that inhibits the Capsaicin (HY-10448)- and acid-induced Ca2+-influx with IC50 of 7 nM and 5 nM in CHO cell. (S)-AMG-628 ameliorates Capsaicin-induced rats flinching, and reverses the thermal hypersensitivity in CFA-(HY-153808) induced inflammatory pain models.
    (S)-AMG-628
  • HY-123428
    MSK-195
    		Agonist
    MSK-195 is a potent agonist of TRPV1, with a potency of 120 nM and an efficacy of 71% in arteriolar response.
    MSK-195
  • HY-103073R
    Mesendogen (Standard)
    		Inhibitor
    Mesendogen (Standard) is the analytical standard of Mesendogen (HY-103073). This product is intended for research and analytical applications. Mesendogen is a TRPM6 inhibitor. Mesendogen enhances the mesoderm and definitive endoderm (DE) differentiations of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Mesendogen can be used for the research of magnesium homeostasis during early embryonic cell development.
    Mesendogen (Standard)
  • HY-121122
    A778317
    		Antagonist
    A778317 is a TRPV1 antagonists. A778317 can block changes in intracellular calcium levels mediated by TRPV1 receptors, with a pIC50 value of 8.31. A-778317 can also block the activation of natural rat TRPV1 receptors in dorsal root ganglion neurons by capsaicin and acid.
    A778317
  • HY-N10612
    Petasin
    		Inhibitor
    Petasin inhibits adipogenesis in cell 3T3-F442A with an IC50 of 0.95 μM. Petasin inhibits the expression of lipid synthesis factors ACC1, FAS and SCD1 by inhibiting transcription factors PPARγ and C/EBPα, as well as targeting TRPA1 and TRPV1 channels . Petasin inhibits mitochondrial complex I, thereby inhibiting tumor growth and metastasis. Petasin activates AMPK signaling pathway, participating in regulation of glucose and lipid metabolism. Petasin is orally active.
    Petasin
  • HY-100208R
    HC-067047 (Standard)
    		Antagonist
    HC-067047 (Standard) is the analytical standard of HC-067047 (HY-100208). This product is intended for research and analytical applications. HC-067047 is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 48 nM, 133 nM, and 17 nM, respectively.
    HC-067047 (Standard)
  • HY-181463
    20-Hydroxy-N-arachidonoyl taurine
    		Activator
    20-Hydroxy-N-arachidonoyl taurine (Compound C20:4 NAT) acts as an activator of TRPV1 and TRPV4, with EC50 values of 28 µM and 21 µM, respectively. 20-Hydroxy-N-arachidonoyl taurine serves as a substrate for fatty acid amide hydrolase (FAAH).
    20-Hydroxy-N-arachidonoyl taurine
  • HY-W554764
    Cyclo(-asp-gly)
    		Activator
    Cyclo(-asp-gly) is a cyclic dipeptide composed of amino acids and is a potential TRPV1 stimulator.
    Cyclo(-asp-gly)
  • HY-181481
    2'-Deoxyadenosine-5'-O-diphosphoribose sodium
    		Agonist
    2'-Deoxyadenosine-5'-O-diphosphoribose sodium is a TRPM2 agonist. 2'-Deoxyadenosine-5'-O-diphosphoribose sodium enhances calcium-induced currents in inside-out patch-clamp experiments using HEK293 cells expressing human TRPM2. 2'-Deoxyadenosine-5'-O-diphosphoribose sodium is a substrate for Nucleoside Triphosphate Diphosphatase 9 (NUDT9).
    2'-Deoxyadenosine-5'-O-diphosphoribose sodium
  • HY-108458R
    SB 452533 (Standard)
    		Antagonist
    SB 452533 (Standard) is the analytical standard of SB 452533 (HY-108458). This product is intended for research and analytical applications. SB 452533 is a potent and selective TRPV1 antagonist with the pKb of 7.8.
    SB 452533 (Standard)
  • HY-104059R
    AMG2850 (Standard)
    		Antagonist
    AMG2850 (Standard) is the analytical standard of AMG2850 (HY-104059). This product is intended for research and analytical applications. AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonist.
    AMG2850 (Standard)
  • HY-105285R
    Piromelatine (Standard)
    		Inhibitor
    Piromelatine (Standard) is the analytical standard of Piromelatine. This product is intended for research and analytical applications. Piromelatine (Neu-P11) is a melatonin MT1/MT2 receptor agonist, serotonin 5-HT1A/5-HT1D agonist, and serotonin 5-HT2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities.
    Piromelatine (Standard)
  • HY-117922
    JYL-79
    		Agonist
    JYL-79 is a TRPV1 agonist with the IC50 of 3.9 nM. JYL-79 can be used for study of neuropathic pain.
    JYL-79
  • HY-186008
    TRPV3 modulator-1
    TRPV3 modulator-1 is a TRPV3 modulator.
    TRPV3 modulator-1
  • HY-117804
    8-Br-cADPR
    		Antagonist
    8-Br-cADPR (8-Bromo-Cyclic ADP-Ribose), a cyclic adenosine diphosphate (ADP)-ribose (cADPR) antagonist, is a TRPM2 ion channel antagonist. 8-Br-cADPR reduces renal damage and the expression of caspase-3 and TRPM2.
    8-Br-cADPR
  • HY-B0545S1
    Probenecid-d7
    		Agonist
    Probenecid-d7 is deuterium-labeled Probenecid (HY-B0545).
    Probenecid-d<sub>7</sub>
Cat. No. Product Name / Synonyms Application Reactivity
TRP Channel Isoform Comparison

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